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PARP inhibition promotes ferroptosis via repressing SLC7A11 and synergizes with ferroptosis inducers in BRCA-proficient ovarian cancer

First, a missed dose : the documented handling is to take it as soon as reasonably possible if several days remain before the next scheduled dose, otherwise skip it never double up to compensate, because two doses close together stacks the incretin effect and reliably provokes GI symptoms

Ageing, smoking, alcohol use and poorly controlled blood sugar add further oxidative load on top